1. Growth retardation - height gain slows and can stop completely with severe weight loss. Growth in height can commence a few months after weight restoration.
2. Pubertal delay or arrest - both height gain and pubertal development are dependent on the release of growth hormone and gonadotrophins (LH and FSH) from the pituitary gland. Suppression of gonadotrophins in patients with anorexia nervosa has been frequently documented.
3. Reduction of Peak Bone Mass - bone accretion is the highest during adolescence, and if onset of anorexia nervosa occurs during this time and stalls puberty, bone mass may remain low
4. Hepatic steatosis - fatty infiltration of the liver.
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